About Me
Chia-Ling Kuo, PhD (she/her/hers)
Associate Professor
The Cato T. Laurencin Institute for Regenerative Engineering
Department of Public Health Sciences, UConn Health
UConn Center on Aging
I am a biostatistician by training. My research areas are in aging, particularly biology of aging and geroscience-guided interventions for aging. I am a NIH-funded investigator, with a track record of grants and publications. I have investigated genes and biomarkers with implications for aging, including APOE and SH2B3 genes, plus telomere length. Part of my research is to relate accelerated biological aging to adverse health outcomes using different biological age measures. More recently, I have focused on drug discovery or repurposing to target the aging process and biology underlying major depressive disorder and Alzheimer's disease and related dementias plus other age-related diseases or conditions. My research is supported by data from UK Biobank and US Health and Retirement Study. I am keen to collaborate to leverage data from additional cohorts for aging-related research.
Research Interests
My research interests include:
- Biology of aging
- Geroscience-guided interventions
- Heterogeneity of aging
- Causal inference methods, e.g., Mendelian randomization and target trial emulation
- Non-linear modeling
- Machine learning
Education
Details of my educational background:
- Ph.D. in Biostatistics, University of Pittsburgh, USA
- M.S. in Biostatistics, National Taiwan University, Taiwan
- B.B.S. in Statistics, National Chengchi University, Taiwan
Publications
Recent publications:
-
Title: "Proteogenomic signature of risk of Alzheimer’s disease and related dementia risk in individuals with a history of major depression disorder"
Authors: Diniz BS, Chen Z, Steffens DC, Pilling LC, Fortinsky RH, Kuchel GA, Kuo CL
Journal: medRxiv
Year: 2024
Preprint
-
Title: "A proteomic signature of healthspan"
Authors: Kuo CL, Chen Z, Liu P, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS
Journal: medRxiv
Year: 2024
Preprint
-
Title: "Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults"
Authors: Kuo CL, Chen Z, Liu P, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS
Journal: Aging Cell
Year: 2024
PMID: 38747160
-
Title: "Polygenic scores for cardiovascular risk factors improve estimation of clinical outcomes in CCB treatment compared to pharmacogenetic variants alone"
Authors: Türkmen D, Bowden J, Masoli JAH, Delgado J, Kuo CL, Melzer D, Pilling LC
Journal: Pharmacogenomics J
Year: 2024
PMID: 38632276
-
Title: "Leukocyte telomere length is associated with MRI-thigh fat-free muscle volume: data from 16,356 UK Biobank adults"
Authors: Kirk B, Kuo CL, Liu P, Xiang M, Earp JE, Kositsawat J, Kuchel GA, Duque G
Journal: J Cachexia Sarcopenia Muscle
Year: 2024
PMID: 38553835
-
Title: "Relationship between baseline plasma p-tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults"
Authors: Pais MV, Kuo CL, Ances BM, Wetherell JL, Lenze EJ, Diniz BS
Journal: Alzheimers Dement
Year: 2023
PMID: 37954547
-
Title: "Does physical activity moderate the association between shorter leukocyte telomere length and incident coronary heart disease? Data from 54,180 UK Biobank participants"
Authors: Xiang M, Pilling LC, Melzer D, Kirk B, Duque G, Liu R, Kuchel GA, Wood AR, Metcalf B, Diniz BS, Hillsdon M, Kuo CL
Journal: Geroscience
Year: 2023
PMID: 37544968
-
Title: "Association between Residential Exposure to Air Pollution and Incident Coronary Heart Disease Is Not Mediated by Leukocyte Telomere Length: A UK Biobank Study"
Authors: Kuo CL, Liu R, Godoy LDC, Pilling LC, Fortinsky RH, Brugge D
Journal: Toxics
Year: 2023
PMID: 37368589
-
Title: "Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants"
Authors: Liu R, Xiang M, Pilling LC, Melzer D, Wang L, Manning KJ, Steffens DC, Bowden J, Fortinsky RH, Kuchel GA, Rhee TG, Diniz BS, Kuo CL
Journal: Aging Cell
Year: 2023
PMID: 37254630
Personal Interests
RV camping, dogs, goldfish, watching sports